Modulation of neural co-firing to enhance network transmission and improve motor function after stroke

Congratulations on LTNr’s new publication in Neuron with collaborators at UCSF entitled, “Modulation of neural co-firing to enhance network transmission and improve motor function after stroke”, which provides neurophysiologic, neuroanatomic, and translational perspectives on application of neurotechnology to improve recovery after stroke.   Authors: Karunesh Ganguly, Preeya Khanna, Robert J. Morecraft, David J. Lin   …

Association of Modified Rankin Scale With Recovery Phenotypes in Patients With Upper Extremity Weakness After Stroke

Congratulations to Dr. Kimberly Erler for her paper, “Association of Modified Rankin Scale with Recovery Phenotypes in Patients with Upper Extremity Weakness after Stroke,” that was published in Neurology and has important implications for stroke clinical trials.   Authors: Kimberly S. Erler, Rui Wu, Julie A. DiCarlo, Marina F. Petrilli, Perman Gochyyev, Leigh R. Hochberg, Steven A. Kautz, Lee H. Schwamm, Steven C. …

Translating concepts of neural repair after stroke: Structural and functional targets for recovery

Authors: Robert W Regenhardt, Hajime Takase, Eng H Lo, David J Lin  Abstract: Stroke is among the most common causes of adult disability worldwide, and its disease burden is shifting towards that of a long-term condition. Therefore, the development of approaches to enhance recovery and augment neural repair after stroke will be critical. Recovery after stroke involves …

Performance and Participation Outcomes for Individuals With Neurological Conditions

Authors: Naomi Josman, Lisa Tabor Connor, David J Lin    Abstract: The goal of this current theme issue was to foster original research papers in neuroscience and rehabilitation science that may serve to address the existing disconnect between disciplines. This platform offered an opportunity for a meaningful exchange of ideas, findings, and practices toward ultimately promoting …

Interdisciplinary Stroke Recovery Research: The Perspective of Occupational Therapists in Acute Care

Authors: Jessica Ranford, Jessica Asiello, Alison Cloutier, Kimberly Cortina, Helena Thorne, Kimberly S. Erler, Natasha Frazier, Caitlin Sadlak, Abigail Rude, and David J. Lin Abstract: As acute stroke treatments advance, more people survive the initial stroke event and live with long-term neurological impairments that impact functional outcomes and quality of life. In accordance with International Classification of Functioning …

New Directions in Treatments Targeting Stroke Recovery

Authors: David J. Lin, Seth P. Finklestein, Steven C. Cramer Stroke is the leading cause of neurological disability in the United States and worldwide. Remarkable advances have been made over the past 20 years in acute vascular treatments to reduce infarct size and improve neurological outcome. Substantially, less progress has been made in treatments to enhance …

Corticospinal Tract Injury Estimated From Acute Stroke Imaging Predicts Upper Extremity Motor Recovery After Stroke

Authors: David J. Lin, Alison M. Cloutier, Kimberly S. Erler, Jessica M. Cassidy, Samuel B. Snider, Jessica Ranford, Kristin Parlman, Fabio Giatsidis, James F. Burke, Lee H. Schwamm, Seth P. Finklestein, Leigh R. Hochberg, Steven C. Cramer Abstract: Background and Purpose — Injury to the corticospinal tract (CST) has been shown to have a major effect on upper …

Changes in input strength and number are driven by distinct mechanisms at the retinogeniculate synap

Authors: David J. Lin, Erin Kang, Chinfei Chen Abstract: Recent studies have demonstrated that vision influences the functional remodeling of the mouse retinogeniculate synapse, the connection between retinal ganglion cells and thalamic relay neurons in the dorsal lateral geniculate nucleus (LGN). Initially, each relay neuron receives a large number of weak retinal inputs. Over a 2- to …