New Directions in Treatments Targeting Stroke Recovery

Authors: David J. Lin, Seth P. Finklestein, Steven C. Cramer Stroke is the leading cause of neurological disability in the United States and worldwide. Remarkable advances have been made over the past 20 years in acute vascular treatments to reduce infarct size and improve neurological outcome. Substantially, less progress has been made in treatments to enhance …

Corticospinal Tract Injury Estimated From Acute Stroke Imaging Predicts Upper Extremity Motor Recovery After Stroke

Authors: David J. Lin, Alison M. Cloutier, Kimberly S. Erler, Jessica M. Cassidy, Samuel B. Snider, Jessica Ranford, Kristin Parlman, Fabio Giatsidis, James F. Burke, Lee H. Schwamm, Seth P. Finklestein, Leigh R. Hochberg, Steven C. Cramer Abstract: Background and Purpose — Injury to the corticospinal tract (CST) has been shown to have a major effect on upper …

Combining Fluoxetine and rTMS in Post stroke Motor Recovery

Authors: Bonin Pinto C., Morales-Quezada .L, de Toledo Piza P.V., Zeng D., Saleh Vélez F.G., Ferreira I.S., Lucena P.H., Duarte D., Lopes F., El-Hagrassy M.M., Rizzo L.V., Camargo E.C., Lin D.J., Mazwi N., Wang Q.M., Black-Schaffer R., Fregni F. Abstract: Background. Although recent evidence has shown a new role of fluoxetine in motor rehabilitation, results are mixed. We …

Stroke Tank Winner: Congratulations to Dr. David J. Lin

Congratulations to Dr. David Lin for presenting a winning pitch at Stroke Tank. The winnings will provide funding to start to scale our MGH SMaHRT (Stroke Motor reHabilitation and Recovery sTudy) to the hospitals in the NECC network.  

Changes in input strength and number are driven by distinct mechanisms at the retinogeniculate synap

Authors: David J. Lin, Erin Kang, Chinfei Chen Abstract: Recent studies have demonstrated that vision influences the functional remodeling of the mouse retinogeniculate synapse, the connection between retinal ganglion cells and thalamic relay neurons in the dorsal lateral geniculate nucleus (LGN). Initially, each relay neuron receives a large number of weak retinal inputs. Over a 2- to …